2016 Fiscal Year Final Research Report
Clinical and bacteriological analysis of nontypeable Haemophilus influenzae isolated from invasive diseases
| Project/Area Number |
26461564
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Chiba University |
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Principal Investigator |
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| Research Collaborator |
HOSHINO Tadashi
HISHIKI Haruka
NAITO Sachiko
TAKEUCHI Noriko
OHKUSU Misako
SEGAWA Shunsuke
TSUCHIDA Sachio
SATOH Mamoru
TAKAHASHI Hiroki
NISHI Junichiro
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | インフルエンザ菌 / Hibワクチン / 無莢膜株 / 薬剤耐性 / MLST解析 / 侵襲性感染症 |
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| Outline of Final Research Achievements |
After the introduction of Haemophilus influenzae type b (Hib) vaccine, invasive H. influenzae infection is now mainly due to nontypeable H. influenzae (NTHi). We investigated the clinical characteristics of invasive NTHi disease in children by clarifying the pathogenicity of NTHi strains isolated from invasive diseases. Most of the strains were biotype II or III. Two β-lactamase positive ampicillin-clavulanate resistant strains were found. Other penicillin non-susceptible strains had multiple amino acid substitutions. The average of biofim formation of hia or pilli positive strains were higher than negative strains. IS1016 was positive in 10.7% of the tested strains. Invasive NTHi strains from our study showed a wide variety of characteristics. Continuous monitoring of the NTHi responsible for invasive diseases in children is important to detect the changes in the epidemiology of invasive H. influenzae infection in the post Hib vaccine era.
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| Free Research Field |
小児感染症
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