Development of a peptide as a novel therapy for brochial asthma

2017 Fiscal Year Final Research Report

• Project/Area Number: 26461565
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Pediatrics
• Research Institution: The University of Tokyo
• Principal Investigator: YASUDO HIROKI 東京大学, 医学部附属病院, 助教 (70422285)
• Co-Investigator(Kenkyū-buntansha): 磯島 豪 帝京大学, 医学部, 講師 (00568230) ; 三牧 正和 帝京大学, 医学部, 教授 (40392419) ; 加藤 元博 国立研究開発法人国立成育医療研究センター, 小児血液・腫瘍研究部, 医長 (40708690)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: 気管支喘息 / 治療 / ペプチド

Outline of Final Research Achievements

We aim to develop a molecular based drug as a novel therapy for bronchial asthma.
In this study, we have shown that the introduction of Src homology region 2 (SH2) domain-containing phosphatase 1 (SHP-1) with TAT vector (protein carrier) have brought a decrease in the total cell counts and eosinophil counts in bronchoalveolar lavage fluid of asthmatic mice. This result shows this therapy could suppress inflammation in respiratory tracts and could be a novel therapy for the disease.

Free Research Field

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