2017 Fiscal Year Final Research Report
Molecular and immunological analysis to clarify the pathogenesis of systemic juvenile idiopathic arthritis
| Project/Area Number |
26461571
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Research Collaborator |
Inoue Natsumi
Mizuta Mao
Takakura Maiko
Sakumura Naoto
Tasaki Yuko
Nakagishi Yasuo
Yachie Akihiro
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Keywords | マクロファージ活性化症候群 / IL-18 / 全身型若年性特発性関節炎 / 成人スティル病 / NK細胞 / IFN-γ |
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| Outline of Final Research Achievements |
We investigated serum cytokine profile in patients with systemic juvenile idiopathic arthritis (s-JIA) and adult onset Still’s disease (AOSD). Furthermore, we sequentially analyzed NK cell activation upon IL-18 in these patients from active phase to remisson. Serum IL-18 levels were extremely elevated in s-JIA and AOSD patients. IL-6 dominant subset was prone to arthritis, while IL-18 dominant subset was prone to develop macrophage activation syndrome (MAS). NK cell activation upon IL-18 was impaired in active phase and recovered after treatment as serum IL-18 levels decreased. Extensive cytokine profile analysis with antibody array revealed IL-18/IFNγ axis play a key role to develop MAS.
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| Free Research Field |
小児リウマチ膠原病学
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