2016 Fiscal Year Final Research Report
Classification of ependymoma of childhood and establishment of molecular diagnositic procedure for molecular target therapy of ependymoma.
| Project/Area Number |
26461573
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatrics
|
|---|
| Research Institution | Matsumoto Dental University |
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Principal Investigator |
|
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| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Keywords | 上衣腫 / SNA array |
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| Outline of Final Research Achievements |
SNP array analysis using 13 samples of childhood ependymoma revealed that they have 1q gain (46%), 2q gain (31%), and 5q loss (15%), respectively. These copy number variations (CNV) are comfirmed by FISH analysis, except for 1 sample of 5q loss. The relationship between these CNV revealed by SNP array and clinical prognosis of ependymoma are not revealed. The relationship between the results of immunostaining of samples (nestin、tenasin-C、NELL2、LAMA2、and KIF27) and clinical prognosis of ependymoma are not revealed, either.
|
| Free Research Field |
小児科学
|
