2016 Fiscal Year Final Research Report
A role and progress process of DAMPs with intractable central nerve infectious disease
| Project/Area Number |
26461590
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Pediatrics
|
|---|
| Research Institution | Fukushima Medical University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Keywords | DAMPs / HMGB1 / 脳炎脳症 / バイオマーカー |
|---|
| Outline of Final Research Achievements |
I examined an epidemiological clinical characteristic of Fukushima of the acute encephalitis and encephalopathy and a factor in conjunction with the convalescence to examine a role of DAMPs in the onset, the progress mechanism of the central nerve infectious disease. Disturbance of consciousness and respiratory failure were bad prognosis.
I made some seriously HUS model mouse. Serum HMGB1 level in seriously HUS mouse ware highest at 6hr and decreased 48hr. So participation of DAMPs was suggested for progress mechanism of the HUS. I searched the inflammatory protein using a cerebrospinal fluid specimen at human acute encephalitis and acute encephalopathy onset. Alpha2 macroglobulin in cerebrospinal fluid increased with the acute disseminated encephalomyelitis, and possibility of acute encephalopathy early biomarker was suggested.
|
| Free Research Field |
小児神経
|
