Analysis of Regenerated Bone Marrow by Adipose-derived stromal cells grown on a hydroxyapatite scaffold

2017 Fiscal Year Final Research Report

• Project/Area Number: 26461595
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Pediatrics
• Research Institution: Nippon Medical School
• Principal Investigator: UEDA TAKAHIRO 日本医科大学, 医学部, 准教授 (20322505)
• Co-Investigator(Kenkyū-buntansha): 右田 真 日本医科大学, 医学部, 助教授 (50256963)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: 間葉系幹細胞 / 脂肪由来間葉系幹細胞 / 人工骨髄 / 造血幹細胞

Outline of Final Research Achievements

Regenerated bone marrow created using mouse adipose-derived mesenchymal cells (ADSC) was confirmed to be able to maintain long-term hematopoietic cells subcutaneously in NOD immunodeficient mice and was demonstrated to have the ability to provide bone marrow niches.　Moreover, the results of an investigation using a murine model of coronary vasculitis to confirm the anti-inflammatory effect of murine ADSC　revealed anti-inflammatory effects and　immune regulatory functions such as inhibition of inflammatory cytokines and reduction of the area of vasculitis; data useful for future elucidation of the mechanism of bone marrow reconstruction were obtained.

Free Research Field

小児血液