Analysis of drug-resistant mechanism in nephroblastoma with WTX abnormality

2016 Fiscal Year Final Research Report

• Project/Area Number: 26461600
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Pediatrics
• Research Institution: Research Institute for Clinical Oncology, Saitama Cancer Center
• Principal Investigator: Masayuki Haruta 埼玉県立がんセンター(臨床腫瘍研究所), 臨床腫瘍研究所, 研究員 (80392190)
• Research Collaborator: Kaneko Yasuhiko 埼玉県立がんセンター, 臨床腫瘍研究所, 参与
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 腎芽腫 / WTX

Outline of Final Research Achievements

In nephroblastoma, identification of new prognostic markers for better therapy planning are needed to improve the mortality and recurrence rate, and prevent side and late effects. We previously showed that WTX abnormality in nephroplastoma were correlated with poor prognosis in Japanese nephroplastoma. Some of nephroblastoma patients are long-term survive without relapse. In nephroblastoma with WTX abnormality, we performed SNP array analysis to clarify chromosomal abnormalities correlated with cancer death in 27 nephroblastoma with WTX abnormality. We couldn't identify chromosomal abnormalities correlated specifically with cancer death or event free. We have been performing comprehensive gene expression analysis for identification of signal pathway correlated with therapy resistance in nephroblastoma with WTX abnormality.

Free Research Field

小児腫瘍