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2017 Fiscal Year Final Research Report

Molecular mechanisms of the left-right axis malformations in pregnancy hyperglycemia

Research Project

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Project/Area Number 26461637
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Embryonic/Neonatal medicine
Research InstitutionKyushu University

Principal Investigator

Kitajima Keiko  九州大学, 医学研究院, 助教 (00332784)

Project Period (FY) 2014-04-01 – 2018-03-31
Keywords糖尿病 / 左右軸 / 先天異常
Outline of Final Research Achievements

We concluded that the embryonic left-right asymmetry disorders due to the pregnancy diabetes is caused by hyperglycemia. The exposure to high glucose levels decreases Nodal and Cerl2 expression in the perinodal cells, and subsequent downregulation of Nodal expression in the left LPM.
We hypothesized that Wnt signaling is required for the primary determination of left-right axis in the node, and identified of the enhancer region of Wnt3a gene promoter and the enhancer binding protein for Wnt3a expression in the PS.

Free Research Field

発生学

URL: 

Published: 2019-03-29  

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