2016 Fiscal Year Final Research Report
New treatment of epidermolysis bullosa by the dermal rearrangement with fibroblasts and mesenchymal stem cells
| Project/Area Number |
26461675
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Dermatology
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| Research Institution | Hirosaki University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Keywords | 表皮水疱症 / 間葉系幹細胞 / 線維芽細胞 |
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| Outline of Final Research Achievements |
In this study, we analyzed the therapeutic possibilities of the dermal fibroblast and mesenchymal stem cells derived from patients of epidermolysis bullosa. We cultured fibroblasts and mesenchymal stem cells from the skin and fat tissue from COLVII-KO mice and injected the cells intradermally in the dorsum of COLVII-KO mice. We revealed that injected cells produced the rearrangement of the dermal condition and removed the irritated skin changes in the COLVII-KO mice.
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| Free Research Field |
皮膚科学
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