2017 Fiscal Year Final Research Report
Change in metabolites and transgenerational effects after rearrangement of brain DNA methylation
| Project/Area Number |
26461711
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Psychiatric science
|
|---|
| Research Institution | Chiba University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2014-04-01 – 2018-03-31
|
| Keywords | DNAメチル化 / エピジェネティクス / 恐怖条件付け / 次世代 |
|---|
| Outline of Final Research Achievements |
DNA methylation is a kind of gene expression control system with no change in the genome. In this study, methyl donor deficient diet was used to rearrangement of DNA methylation in the brain of mice during 3wk to 6wk of age after weaning. The author investigated the effect of the diet on the behavior and gene expression and change of metabolites in the hippocampus, and also those alterations int the next generation. As a result, F1 mice which has the father wit methyl deficient diet history showed different behaviors especially in the fear conditioning and extinction paradigm and gene expressions and metabolites changes in the hippocampus compared to the control mice. The results suggest that the alteration in the brain DNA methylation affects behaviors, gene expressions, and metabolites in the next generation.
|
| Free Research Field |
精神医学
|
