2016 Fiscal Year Final Research Report
NrCAM develops brain neural network and behavioral phenotypes of addiction.
| Project/Area Number |
26461716
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Psychiatric science
|
|---|
| Research Institution | University of Yamanashi |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Keywords | NrCAM / 脳神経ネットワーク / グルタミン酸神経 / GABA神経 / ドパミン神経 / 覚せい剤依存 / コカイン依存 |
|---|
| Outline of Final Research Achievements |
Substance dependence shows certain behavioral characteristics, such as novelty seeking sociability, obsessiveness, depression and anxiety besides preference. However, there is no medicine developed by understanding of the disease. Our previous study evaluated NrCAM that works in vulnerability to addiction. We therefore evaluated several neural molecules that changed their gene expression by methamphetamine administration, in addition, differently by low Nrcam expression. Among those, 5 genes were differently changed their expression also by cocaine administration in mice. Those glutaminergic, GABAergic, dopaminergic molecules could be new therapeutic targets for substance non-specific addiction.
|
| Free Research Field |
精神医学、遺伝医学、神経科学
|
