Development of cerebrospinal fluid miRNA marker for psychiatric disorders

2016 Fiscal Year Final Research Report

• Project/Area Number: 26461731
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: National Center of Neurology and Psychiatry
• Principal Investigator: Hattori Kotaro 国立研究開発法人国立精神・神経医療研究センター, 神経研究所, 室長 (50415569)
• Research Collaborator: KUCHIKI Yukie
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: バイオマーカー / 精神疾患 / 脳脊髄液 / マイクロRNA

Outline of Final Research Achievements

In this study, we aimed to develop microRNA biomarkers in cerebrospinal fluid for psychiatric disorders including schizophrenia and depression. Using cerebrospinal fluid microarray analyses data of total 116 cases including schizophrenia, depression, bipolar disorder and healthy controls, we selected 193 candidate molecules. We then performed quantitative PCR analyses on a part of candidate molecules, and found that only a part of those molecules with high expression levels could be measured with certain precision. Thus, from the viewpoint of practicality, we narrowed the candidate marker to 40 molecules. Among those molecules, miR-3620-5p, was markedly increased in a subpopulation of depression, whereas miR-1908 was significantly correlated with depressive symptoms. Future studies are warranted to verify those candidate markers, especially to develop new classification and treatment for psychiatric disorders.

Free Research Field

分子精神医学