2017 Fiscal Year Final Research Report

Disruptions of neuronal connectivity of white matter in patients with schizophrenia, mood disorders by using functional connectivity and diffusion tensor imaging analysis.

Research Project

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Project/Area Number	26461754
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Psychiatric science
Research Institution	Wakayama Medical University
Principal Investigator	Shinosaki Kazuhiro 和歌山県立医科大学, 医学部, 博士研究員 (40215984)
Co-Investigator(Kenkyū-buntansha)	鵜飼聡和歌山県立医科大学, 医学部, 教授 (80324763) 辻富基美和歌山県立医科大学, 医学部, 准教授 (10347586) 小瀬朝海和歌山県立医科大学, 医学部, 助教 (10405425) 山本眞弘和歌山県立医科大学, 医学部, 助教 (80423937) 坂本友香和歌山県立医科大学, 医学部, その他 (90423938) 高橋隼和歌山県立医科大学, 医学部, その他 (10508021) 山田信一和歌山県立医科大学, 医学部, 助教 (70549716) 大沢恭子和歌山県立医科大学, 医学部, 学内助教 (50612107) 金桶吉起和歌山県立医科大学, 医学部, 教授 (20280589)
Project Period (FY)	2014-04-01 – 2018-03-31
Keywords	統合失調症 / 双極性障害 / 大うつ病 / 拡散強調画像 / functional MRI / ミエリン / 異方性 / functional connectivity
Outline of Final Research Achievements	We studied white matter abnormalities in patients with schizophrenia, major depression, bipolar disorder by MRI diffusion tensor image / anisotropy factor FA, resting function MRI / functional connectivity analysis, T1 / T2 ratio myelin weighted image. In schizophrenia, myelin injury was confirmed in a wide range, and the blood ω - 3 fatty acid correlated with cognitive functions. Both bipolar disorder and major depression, decrease FA values were found in anterior part of corpus callosum frontal lobe which connect both prefrontal cortices. In major depression, FA value correlated with executive function and attention function. In bipolar disorder, interhemispheric functional connectivity dysfunction in the sensorimotor area is associated with the FA value in the corpus callosum and functional within-connectivity was related to Young Mania-Rating Scale. The next task is to improve the neural network by rTMS, ω3 fatty acid and confirm the therapeutic effect.
Free Research Field	精神医学