Cross sectional and longitudinal studies of bone fragility with clinical CT-based finite element analysis

2016 Fiscal Year Final Research Report

• Project/Area Number: 26461792
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Hiroshima University
• Principal Investigator: Takasu Miyuki 広島大学, 病院(医), 病院助教 (70565647)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 続発性骨粗鬆症 / 多発性骨髄腫 / 有限要素法

Outline of Final Research Achievements

The prevalence of osteoporosis was significantly higher in post TACE patients than in control subjects. The cumulative radiation dose related to routine dynamic CT studies was a significant contributor to the prevalence of osteoporosis. MDCT demonstrated that bone strength and bone mass were not significantly reduced in patients who underwent ASCT compared with the bortezomib group. Osteoporosis does not appear to be a long-term complication of ASCT. Lenalidomide treatment resulted in significant increases in CT/FEM-derived estimates of bone strength. Response to chemotherapy predicted lenalidomide-induced bone changes and good responders had increased bone strength. The validation of MDCT against gold-standards CBCT suggests that indices of bone quality including BV/TV may be appropriate for clinical monitoring of bone quality by MDCT. Iterative reconstruction improved the correlation between 64-section MDCT and micro-CT-derived metric parameters.

Free Research Field

放射線診断学