Hybrid MRI contrast agent and basic comparison of performance with other contrast agents using animal experiment

2016 Fiscal Year Final Research Report

• Project/Area Number: 26461807
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Komazawa University
• Principal Investigator: Shimada Morio 駒澤大学, 医療健康科学部, 教授 (20196489)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: MRI / 造影剤 / 蛍光イメージング / コラーゲンペプチド / Gd / マウス

Outline of Final Research Achievements

Evaluation of lymph flow in interstitium was possible with iron preparation. Depending on the selection of the particle diameter and dilution concentration, there are cases in which contrast imaging is not available, and appropriate selection is necessary.We prepared a mouse of NASH model as a material to evaluate liver function and compared it with normal mouse.We administered ICG to both groups of mice. We imaged by IVIS every 5 minutes, And analyzed these images.As a result of examination, the progression of NASH could be detected from the fluorescence by ICG.A novel conjugate, PHG10 dye, was synthesized using a collagen peptide and a near-infrared (NIR)-responsive dye to achieve targeted cytotoxicity.Using biopolymer PPG as a starting material, Gd-PPG was obtained through multi-step synthesis process.

Free Research Field

MRI　造影剤　動物実験