The early evaluation of the responsiveness in molecular target drugs and the visualization of liver function by the MRI molecular imaging.

2017 Fiscal Year Final Research Report

• Project/Area Number: 26461844
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Aichi Cancer Center Research Institute
• Principal Investigator: Matsushima Shigeru 愛知県がんセンター(研究所), 分子腫瘍学部, 研究員 (70444297)
• Research Collaborator: KINOSADA Yasutomi ; ERA Seiichi ; INABA Yoshitaka ; SATO Yozo ; MURATA Shinichi
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: 癌 / 早期治療効果判定 / 分子画像 / 細胞密度画像 / 機能画像 / 磁気共鳴 / 磁化移動効果

Outline of Final Research Achievements

The purpose of this work is to perform the reactant early evaluation in molecular target drugs, and an exploitation of a surgery support liver-function imaging using MRI. To evaluate and compare the usefulness of equivalent cross-relaxation rate (ECR) imaging (ECRI) in the early prediction of the response of molecular target drugs treatments of colorectal liver metastases. In the response assessment to chemotherapy, the pretreatment ECR values were significantly higher in the responders group than in the non-responders group, and the 2 weeks after the ECR values were significantly lower. To evaluate posthepatectomy liver failure using gadoxetic acid-enhanced MRI with a measure of relative liver enhancement image (RLEI) on hepatobiliary phase images, thereby facilitating safe liver resection. This MRI examination method also provides morphological and functional information that can be used to optimize the preoperative selection of patients who can safely undergo liver resection.

Free Research Field

医歯薬学