2016 Fiscal Year Final Research Report
The molecular mechanism of radiation-induced acceleration of atherosclerosis
| Project/Area Number |
26461852
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Fukushima Medical University (2016)
Hiroshima University (2014-2015) |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | DNA損傷 / 動脈硬化 / 放射線被ばく |
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| Outline of Final Research Achievements |
It has been well recognized that radiotherapy increases the risk of atherosclerotic cardiovascular disease. The object of this study was to clarify the mechanism of radiation-induced acceleration of atherosclerosis. Thoracic aorta of apoE-deficient (apoE-KO) mice were irradiated with the dose of 10Gy and kept on a normal chow diet for 8 weeks. The plaque area was significantly increased in aortic roots of irradiated apoE-KO mice compared with control mice. Infiltration of inflammatory cells and hemorrhage was observed in the plaque. Additionally, immunohistochemical study revealed that gamma-H2AX and phospho-ATM staining were increased in the plaque of irradiated apoE-KO mice. These results suggest that accumulation of DNA damage and activation of DNA damage response is involved in the mechanism of radiation-induced acceleration of atherosclerosis.
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| Free Research Field |
動脈硬化
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