Clinical research for EMSB to obatain PET/SPECT images of Amyloidosisin AD and FAP

2017 Fiscal Year Final Research Report

• Project/Area Number: 26461861
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Kumamoto University
• Principal Investigator: Tomiyoshi Katsumi 熊本大学, 大学院生命科学研究部(保), 教授 (60188802)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: 全身性アミロイド―シス / 標識薬剤 / 18FEFSB / 最適合成条件 / 放射性標識薬剤 / 125I-EISB / 最適反応時間

Outline of Final Research Achievements

we made a precursor EMSB and 19F-EFSB labeled stable isotope fluorine on EMSB to develop a new imaging probe18F-EFSB that detects systemic amyloidosis by PET examination. As a result of histochemical analysis, 19F-EFSB specifically accumulated in all disease type amyloid. 18F-EFSB was efficiently labeled with a radiochemical purity of 81.7 ± 5.1%(n=3) by reaction at 200 degree. for 5 minutes.
We also determined the optimal synthesis time and clarify stability of 125I-EISB in saline and human serum, respectively. As a result,high radioactive purity 95.88±3.19% was obtained in 10 minutes by our synthesis and the radiochemical purity was97.83±1.40% (n=6) applying our purification system.

Free Research Field

放射性薬剤