Experimental study of selective portal vein embolization for nonalcoholic steatohepatitis in rabbit model

2016 Fiscal Year Final Research Report

• Project/Area Number: 26461865
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Kagoshima University
• Principal Investigator: hayashi sadao 鹿児島大学, 医歯学域附属病院, 助教 (10549918)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 門脈塞栓術 / 脂肪肝

Outline of Final Research Achievements

After portal embolization, sinusoidal obstruction grade was significantly worsen in remnant liver lobe of rabbit NAFLD model. SMA staining area was significantly larger in each remnant liver lobe compared with normal control and NAFLD control liver. which means Portal vein embolization(PVE) induced the fibrotic change in not only embolized liver lobe and remnant lobe.
These findings suggest that PVE induce the liver damage in remnant lobe. particular in fatty change liver, it was considered that fatty change and PVE induce sinusoid obstruction. We think sinusoid obstruction and liver fibrosis in future remnant liver would be the risk of unexpected fatal liver damage cannot be excluded in the patients with NAFLD after PVE.

Free Research Field

ＩＶＲ