Evaluation of body BPA distribution by F-BPA PET examination and study of the SUV change of F-BPA

2016 Fiscal Year Final Research Report

• Project/Area Number: 26461873
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: National Cancer Center Japan
• Principal Investigator: Itami Jun 国立研究開発法人国立がん研究センター, 中央病院, 科長 (40505377)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: FBPA PET / ホウ素中性子補足療法

Outline of Final Research Achievements

In boron neutron capture therapy (BNCT), treatment is performed by thermal neutron irradiation to the tumor tissue which selectively accumulates intravenously infused BPA. PET examination using FBPA is valuable to predict selective BPA accumulation in the tumor tissue. In this study, one-shot and infusion injections of FBPA shows similar uptakes in normal as well as tumor tissues 60 minutes after injection, and the uptakes predict well the BPA concentrations delivered with drip infusion. The uptakes in normal and tumor tissues seen in FBPA PET examination showed proportionality with the boron concentrations after the BPA drip infusion. Some kinds of amino acids increased uptake of FBPA in tumor tissues, which was not seen in normal tissues. The results suggest that pretreatment with such amino acids can be used as an enhancer of BNCT effect.

Free Research Field

放射線腫瘍学