Volumetric modulated arc therapy for thoracic esophageal cancer to decrease radiotherapy-induced herat toxicity

2016 Fiscal Year Final Research Report

• Project/Area Number: 26461890
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Hiroshima University
• Principal Investigator: Murakami Yuji 広島大学, 医歯薬保健学研究院(医), 講師 (10403528)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 胸部食道癌 / 強度変調回転照射 / VMAT / 晩期心毒性 / Automated-planning

Outline of Final Research Achievements

We established the IGRT system of VMAT for thoracic esophageal cancer patients using immobilization with Vac-lock, bone-matching with OBI and CBCT-matching. We analyzed the physiological esophageal movement. There were remarkable individual differences in the movement, so we considered that setting conformal PTV margins was not suitable. Evaluation of inter-fractional displacement of esophageal position under breath-hold situation showed minimal.
Using automated VMAT planning engine, improvement of target dose conformity, significant reduction of high-middle dose area in whole heart, left ventricle, pericardium, lung and liver. Low dose area (D5) in all lung was maintained under 50% in 10/12 patients, and the maximum D5 among study patients was under 55%. We consider the automated planning system can introduce VMAT for thoracic esophageal cancer patients.

Free Research Field

放射線治療