Novel treatment for non-alcoholic hepatitis inducing human brown adipose tissue

2017 Fiscal Year Final Research Report

• Project/Area Number: 26461925
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General surgery
• Research Institution: Jichi Medical University
• Principal Investigator: SAKUMA YASUNARU 自治医科大学, 医学部, 准教授 (10296105)
• Co-Investigator(Kenkyū-buntansha): 三木 厚 自治医科大学, 医学部, 講師 (20570378) ; 安田 是和 自治医科大学, 医学部, 客員教授 (40158001) ; 上本 伸二 京都大学, 医学研究科, 教授 (40252449) ; 笠原 尚哉 自治医科大学, 医学部, 助教 (50382891) ; 寺谷 工 自治医科大学, 医学部, 講師 (70373404) ; 藤本 康弘 京都大学, 医学研究科, 客員研究員 (80335281)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: 褐色脂肪細胞 / 表面マーカー / 細胞移植 / 褐色細胞腫

Outline of Final Research Achievements

Brown adipocytes play a central role in regulating metabolism and generating　metabolic signals. They are also important to maintain metabolic homeostasis by adjusting energy expenditure. However, these cells are not yet well-understood and the tissue-specific presence of uncoupling protein 1 (UCP-1) is a promising lead to gain further understanding. Pheocromocytomas are known to have a tendency to grow into surrounding adipose tissue and become brown adipose tissue. We have successfully collected and cultured these cells from a patient with a pheocromocytoma. There is very little knowledge about Brown adipocytes except for the presence of UCP-1. We performed fluorescence-activated cell sorting combined with a UCP-1 specific aptamer. Cell surface makers were detected using gene-tip analysis and showed CD9, CD177, CD200：positive、and CD40, CD44, CD109: negative.

Free Research Field

膵島細胞移植