2016 Fiscal Year Final Research Report
Role of mast cell serine protease (chymase) on acute liver failure
| Project/Area Number |
26461932
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Osaka Medical College |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 急性肝不全 / キマーゼ / ＭＭＰ / 阻害薬 / 肥満細胞 / マウス |
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| Outline of Final Research Achievements |
The role of mast cell serine protease (chymase) was investigated in a mouse acute liver failure model. Hepatic chymase activity was significantly increased just after lipopolysaccharide/D-galactosamine (LPS+Galn) injection. Seven hours after LPS+Galn injection, MMP-9, TNF-and MPO were increased, but they were significantly suppressed by treatment with chymase inhibitor 1 hour after LPS+Galn injection, resulting in the increase of survival rate after LPS+Galn injection. Chymase plays an important role in the development of acute liver failure, and chymase inhibitor prevente the acute liver failure.
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| Free Research Field |
一般・消化器外科学
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