2016 Fiscal Year Final Research Report
Effects of glucocorticoid receptor on aromatase expression
| Project/Area Number |
26461939
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Gunma University |
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Principal Investigator |
Horiguchi Jun 群馬大学, 大学院医学系研究科, 准教授 (70272242)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | アロマターゼ / RORα / ERα |
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| Outline of Final Research Achievements |
It was discovered that the expression of aromatase is controlled by RORα, and the ROR response area was identified on the aromatase gene. Further, it was confirmed that proliferative activity of estrogen-sensitive breast cancer cell lines was activated by the aromatase gene. There was a positive correlation between RORα or GR and aromatase expression in breast cancer tissue. Promoter A was significantly higher in ERα-positive breast cancer cell lines and ERα-positive clinical specimens. The correlation between STS and OATP 3A1 was particularly high in the primary tumor of ER-positive breast cancer.
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| Free Research Field |
外科学一般
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