2016 Fiscal Year Final Research Report
Analysis of gene expression involved in the prognosis and occurrence site of gastrointestinal stromal tumors
| Project/Area Number |
26461970
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Niigata University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 消化管間質腫瘍 |
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| Outline of Final Research Achievements |
Gastrointestinal stromal tumor (GIST) of the small intestine has poor prognosis compared to that of the stomach. We focused on the involvement of the DNPH1 gene, which is known to be involved in autonomous cell proliferation and tumorigenesis. We confirmed that GISTs of the small intestine had high malignant potential clinically and examined the expression of DNPH1 using surgically resected specimens. DNPH1 expression were clearly observed in GIST specimens both of the small intestine and of the stomach. Although differences of the DNPH1 expression due to differences in primary organs was not clear, the expression of DNPH1 may contributes to tumor involvement.
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| Free Research Field |
消化器外科学
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