Identification of biomarker for peritoneal dissemination from gastric cancer: analysis of lnc RNA

2016 Fiscal Year Final Research Report

• Project/Area Number: 26461975
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Mie University
• Principal Investigator: Mohri Yasuhiko 三重大学, 医学系研究科, 准教授 (70345974)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 胃癌 / 腹膜播種

Outline of Final Research Achievements

The prognosis of gastric cancer (GC) patients with peritoneal dissemination remains poor, and a better understanding of the underlying mechanisms is critical for the development of new treatments that will improve survival in these patients. This study aimed to clarify the clinical and biological role of two key metastasis-associated long non-coding RNAs (lncRNAs) in GC. We analyzed the expression levels of two lncRNAs in gastric tissues. Expression of 2 lncRNAs was significantly higher in cancerous tissues than in corresponding normal mucosa, and higher expression of these lncRNAs significantly correlated with peritoneal metastasis in GC patients.Our data provide novel evidence for the biological and clinical significance of HOTAIR expression as a potential biomarker for identifying patients with peritoneal metastasis, and as a novel therapeutic target in patients with gastric neoplasia.

Free Research Field

胃癌