Comprehensive analysis and treatment strategy of MicroRNA that regulates peritoneal metastasis of gastric cancer

2016 Fiscal Year Final Research Report

• Project/Area Number: 26461976
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Mie University
• Principal Investigator: Okigami Masato 三重大学, 医学系研究科, リサーチアソシエイト (90722596)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 胃癌 / microRNA / 腹膜播種 / 遠隔転移

Outline of Final Research Achievements

Comprehensive microRNA (miRNA) analysis was analyzed for expression of microRNAs from gastric cancer tumor tissue and normal tissue. MiRNAs involved in epithelial mesenchymal transition correlated with distant metastasis of gastric cancer. Serum miR-203 was identified and it was shown that it was significantly lower in stage IV gastric cancer patients than in stage I - III gastric cancer patients, and this low expression was found to be an independent predictive marker of poor prognosis in gastric cancer patients.
The fact that MTA-1 expression in gastric cancer tissues is useful as a peritoneal dissemination predictor, and that the high expression of gastric cancer tissue ANGPTL 2 and the increase in ANGPTL 2 concentration in serum correlate with peritoneal dissemination and are useful for differentiation of poor prognosis group Indicated.

Free Research Field

消化管外科