Effect of microRNA on peritoneal dissemination in gastric cancer

2016 Fiscal Year Final Research Report

• Project/Area Number: 26461989
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Kyoto Prefectural University of Medicine
• Principal Investigator: ICHIKAWA DAISUKE 京都府立医科大学, 医学(系)研究科(研究院), 准教授 (20347446)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 胃癌 / 腹膜播種 / exosome

Outline of Final Research Achievements

TEX were internalized in both mesothelial and gastric cancer cells in a cellular origin non-specific manner. Internalization of TEX into mesothelial cells promoted significant adhesion between mesothelial and gastric cancer cells, and TEX internalization into gastric cancer cells significantly promoted migratory ability, while internalization of mesothelial cell-derived exosomes did not. Expression of adhesion-related molecules, such as fibronectin 1 (FN1) and laminin gamma 1 (LAMC1), were increased in mesothelial cells after internalization of TEX from gastric cancer cell line and malignant pleural effusion. TEX may play a critical role in the development of peritoneal metastasis of gastric cancer, which may be partially due to inducing increased expression of adhesion molecules in mesothelial cells.

Free Research Field

消化器外科