The development of molecular target drug through the control of IL23/Th17 pathway in tumor microenvironment.

2016 Fiscal Year Final Research Report

• Project/Area Number: 26461993
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Wakayama Medical University
• Principal Investigator: Iida Takeshi 和歌山県立医科大学, 医学部, 博士研究員 (30453187)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: IL-17 / IL-23 / IL-21 / 胃癌 / 腫瘍微小環境

Outline of Final Research Achievements

In the patients who underwent curative resection, IL-17 mRNA expression levels in peritoneal lavage increased according to the depth of tumor invasion.
To examine the correlation of IL-17 production between in peritoneal lavage and in the primary tumor tissue, we performed immunohistochemical staining for IL-17 of primary tumor in the same patients samples. In the primary tumor tissues, IL-17 immunoreactive cells were detected at the cytoplasm in mononuclear cells; however none of the tumor cells were stained for IL-17. IL-17 producing cells in tumor tissues were 7.30 ± 0.82 (mean ± SE) per field. There were no correlation between IL-17 positive cells in tumor tissues and IL-17 mRNA expression in peritoneal wash (r=0.092, p=0.329). It was suggested that IL-17 locally expressed in the tumor would be a potential therapeutic target for treatment of patients with advanced gastric cancer.

Free Research Field

癌微小環境