Investigation of regulating system in histone mRNA and microRNA expression in upper digestive tract cancer

2016 Fiscal Year Final Research Report

• Project/Area Number: 26461994
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Iwate Medical University
• Principal Investigator: Iwaya Takeshi 岩手医科大学, 医学部, 講師 (70405801)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: ヒストンmRNA / microRNA / 胃癌 / 食道癌

Outline of Final Research Achievements

Upregulation of multiple histone mRNA and downregulation of several microRNA (miR-760, miR-1276, and miR-4766-5p) which were targeting 3' untranslated regions of histone mRNAs were observed in gastric adenocarcinoma and esophageal squamous cell carcinoma. However, overexpression of these microRNAs could not change the cellular function of histone mRNA expression in cancer cells. Therefore, another mechanism is thought to be involved in regulating histone mRNA and microRNAs except for direct binding od these RNAs. In this study, we proposed a new mechanism that circular RNA might act as microRNA sponges and downregulated histone mRNAs in gastric cancer cells.

Free Research Field

消化器外科学