Comprehensive analysis of mutation in PI3K/AKT pathway genes in esophageal cancer.

2016 Fiscal Year Final Research Report

• Project/Area Number: 26461999
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Kumamoto University (2015-2016); Japanese Foundation for Cancer Research (2014)
• Principal Investigator: SHIGAKI Hironobu 熊本大学, 医学部附属病院, 非常勤診療医師 (30594874)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 食道癌 / 遺伝子変異 / PIK3CA / 喫煙・飲酒 / Pyrosequence

Outline of Final Research Achievements

In esophageal squamous cell carcinoma (ESCC), compared with the smoking and drinking (SD) group, the non-smoking and non-drinking (NSND) group included more females and those who had family history of the esophageal cancer. The incidence of multiple lesion was significantly lower, and the rate of histological grade G1 was higher in the NSND group compared to the SD group. Further analysis is needed to clarify difference in molecular mechanisms during carcinogenesis between both groups.
Several mutations in various cancers have been linked to APOBEC3B, suggesting a crucial role for this protein in carcinogenesis and cancer development. In ESCC, APOBEC3B expression was significantly correlated with PIK3CA mutation, particularly with C to T transitions of PIK3CA. Given the crucial roles of PIK3CA mutation, our findings might provide new insights into the biological mechanisms of ESCC tumorigenesis and progression.

Free Research Field

消化器外科学