2016 Fiscal Year Final Research Report
SN-38 as a radio-sensitizer for colorectal cancer by suppressing radiation-induced HIF-1a overexpression
| Project/Area Number |
26462005
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Digestive surgery
|
|---|
| Research Institution | The University of Tokyo |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Keywords | 放射線療法 / SN-38 / HIF-1α |
|---|
| Outline of Final Research Achievements |
HIF-1a is the key molecule induced by hypoxia. It activates various pathways protecting cell and tissue from hypoxic stress. Radiotherapy is one of the standard therapy for colorectal cancer, and we found that radiation induced HIF-1a in colorectal cancer cells. We also found that SN-38, which is widely used as an anti-cancer drug for colorectal cancer, effectively suppressed HIF-1a induced by radiation. SN-38 was demonstrated to be a promising radio-sensitizer for colorectal cancer.
|
| Free Research Field |
腫瘍外科
|
