2016 Fiscal Year Final Research Report
Role of Surtuins in the carcinogenesis of colitis-associated cancer
| Project/Area Number |
26462009
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Hamamatsu University School of Medicine |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 炎症性腸疾患 / 発癌 / 低酸素 / Sirtuin |
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| Outline of Final Research Achievements |
First, we assessed the Sirtuins expression level and acetylation level of its downstream target proteins in colorectal cancer cell lines after cytokine stimulation. However, these levels were not detected. In CAC mouse model, we analyzed the Sirtuins expression levels. However, the Sirtuins expression levels were not significantly different. Next, we analyzed the Sirtuins expression levels in surgically resected human CAC samples by immunohistochemistry. We found that the expression level of Sirt-1 and -7 were significantly suppressed in CAC.
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| Free Research Field |
下部消化管外科
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