DNA methylation biomarkers predict development of UC-associated colorectal neoplasia

2016 Fiscal Year Final Research Report

• Project/Area Number: 26462011
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Mie University
• Principal Investigator: Toiyama Yuji 三重大学, 医学部附属病院, 講師 (00422824)
• Research Collaborator: FUJIKAWA HIROYUKI 三重大学, 医学部附属病院, 助教 (40616091) ; KONDO SATORU 三重大学, 医学部附属病院, 医員 (60763737) ; HIRO JYUNICHIRO 三重大学, 医学部附属病院, 助教 (70444437)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: DNAメチル化 / マイクロRNA / 潰瘍性大腸炎 / 癌化

Outline of Final Research Achievements

Colitis-associated cancer (CAC) is higher among long-standing ulcerative colitis (UC) patients, such as that for whom surveillance colonoscopy is widely recommended. However, CAC is often difficult to detect endoscopically and histologically because of mucosal structure modifications by inflammation. Therefore, several molecular alterations may be promising as markers for identifying patients at high risk of developing CAC First, we investigated the feasibility of using the methylation status of several microRNAs, which have characteristic of both type C (methylated during carcinogenesis) and type A (methylated during aging) simultaneously as a promising biomarker in CAC. We next performed the analysis of these biomarkers from rectal biopsy specimen has robust predictive potential in identifying UC patients with CAC elsewhere in the colorectum. In addition, we confirmed the reproducibly by using a large cohort.

Free Research Field

消化器癌