2016 Fiscal Year Final Research Report
Feasibility and efficacy of autologous adipose-derived stem cell therapy for inflammatory bowel disease patients
| Project/Area Number |
26462012
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Keywords | 炎症性腸疾患 / 潰瘍性大腸炎 / クローン病 / 脂肪由来幹細胞 |
|---|
| Outline of Final Research Achievements |
The number of adipose-derived stem cells contained in the subcutaneous adipose tissue of inflammatory bowel disease (IBD) patients was significantly larger than that of Non-IBD patients. Autologous subcutaneous adipose tissue derived stem cell transplantation for refractory postoperative enterocutaneous fistula could be safely performed on IBD patients and was effective in the short term. In experiments using murine adipose-derived stem cells, proliferation and motility were significantly enhanced by the addition of TNF-α.
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| Free Research Field |
医歯薬学
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