2016 Fiscal Year Final Research Report
Development of anti-cancer therapy by control of transposon
| Project/Area Number |
26462028
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
|
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| Research Institution | Tokyo Women's Medical University |
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Principal Investigator |
|
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| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Keywords | レトロポゾン / 抗がん剤 / 大腸がん |
|---|
| Outline of Final Research Achievements |
Growth of colorectal cancer cell lines are inhibited by suppression of LINE-1. LINE-1 was located in stress granule, suggesting that microRNA expression is involved in the mechanism by which knockdown of LINE-1 inhibit cancer growth. However, further experiment shows no evidence that the microRNA expression is involved in the association between knockdown of LINE-1 and inhibiting cancer growth. Further experiment is needed for controlling LINE-1 ORF1 expression as a molecular target of cancer therapy.
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| Free Research Field |
腫瘍学
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