Development of artificial liver support system from view of liver immunity and liver regeneration

2016 Fiscal Year Final Research Report

• Project/Area Number: 26462040
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: University of Yamanashi
• Principal Investigator: FUJII Hideki 山梨大学, その他部局等, 理事 (30181316)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 人工肝補助装置 / 肝クッパー細胞 / 肝細胞癌 / 肝炎 / 肝再生 / IL-17A / M-CSF / CLEC-2

Outline of Final Research Achievements

It is very important to clarify the mechanism of the liver diseases for considering an indication of artificial liver support system to the liver diseases such as HCC, hepatitis and liver regeneration. As HCC, IL-17A plays a pivotal role in chemically induced hepatic carcinogenesis, which is most likely through inflammation-initiated oxidative DNA damage and cell proliferation. And M-CSF increases hepatocarcinogenesis, most likely by enhancing an angiogenic factor derived from hepatic MΦ. As hepatitis, IL-17A is a key regulator in hepatic injury caused by neutrophil-induced inflammatory responses after LPS/GalN injection. As liver regeneration C-type lectin receptor-2 (CLEC-2) accelerates the liver regeneration after hepatectomy.

Free Research Field

医歯薬学