Clinicopatholigcai and molecula biological analysis of carcinogenesis induced by chemicals

2016 Fiscal Year Final Research Report

• Project/Area Number: 26462048
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Osaka City University
• Principal Investigator: Kubo Shoji 大阪市立大学, 大学院医学研究科, 准教授 (80221224)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 職業性胆管癌 / 1,2-ジクロロプロパン / ジクロロメタン / 肝内胆管癌 / 前癌病変 / 遺伝子異常 / 多段階発育

Outline of Final Research Achievements

The analysis of occupational cholangiocarcinoma showed that young age, high gamma-GTP level, regional dilation of intrahepatic bile duct, the presence of biliary intraepithelial neoplasia（BilIN）and intraductal neoplasm of the bile duct（IPNB）as well as invasive cholangiocarcinoma are characteristics of the carcinoma. The molecular biological studies showed that such lesions had hypermutation of DNA. These results indicate that some chemicals induced DNA injury, inducing premalignant lesions such as BilIN and IPNB, eventually developing invasive cholangiocarcinoma in the occupational cholangiocarcinoma.

Free Research Field

外科学