2016 Fiscal Year Final Research Report
Effect of chymase inhibitor on fulminant hepatitis
| Project/Area Number |
26462050
|
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
|
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| Research Institution | Osaka Medical College |
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Principal Investigator |
|
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| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Keywords | 劇症肝炎 / キマーゼ / ＭＭＰ / 阻害薬 / 肥満細胞 / ハムスター |
|---|
| Outline of Final Research Achievements |
The effect of chymase inhibitor was investigated in fulminant hepatitis induced by lipopolysaccharide/D-galactosamine in hamsters. Hepatic chymase activity, MMP-9 activity and TNF-α concentration were extremely increased, and increases of hepatic necrosis and plasma AST and ALT were observed. Chymase inhibitor reduced not only hepatic chymase activity but also hepatic MMP-9 activity and TNF-α concentration, resulting in prevention of hepatic necrosis. Chymase inhibitor was useful to prevent the progression of fulminant hepatitis.
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| Free Research Field |
一般・消化器外科学
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