2016 Fiscal Year Final Research Report
Prediction of Chemotherapy Response to Pancreatic Cancer Using Photodynamic diagnosis
| Project/Area Number |
26462055
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Niigata University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Keywords | 膵癌 / 5-ALA / 光線力学診断 |
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| Outline of Final Research Achievements |
Preoperative administration of 5-ALA induces fluorescence of specimens in pancreatic cancer. Fifteen pancreatic cancer patients were preoperatively given 5-ALA and fluorescence patterns of their specimen were observed. We categorized to three patterns (Category 0; no fluorescence, Category 1; fluorescence in spotted or small area, Category 2; fluorescence in whole area). The survival rate of the patients was significantly higher in Category 2 group than in category 0 and 1 group. The experiments using pancreatic cancer cell lines showed that 5-ALA induced fluorescence intensity is correlated to the response rate to gemcitabine.
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| Free Research Field |
消化器外科
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