Elucidation of selection mechanism of disseminated cancer cells in metastatic organs

2016 Fiscal Year Final Research Report

• Project/Area Number: 26462064
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Kyushu University
• Principal Investigator: ONIMARU Manabu 九州大学, 医学研究院, 共同研究員 (80529876)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 膵癌 / 肝転移 / CD110 / トロンボポエチン(TPO)

Outline of Final Research Achievements

To elucidate the mechanism of liver metastasis of pancreatic cancer, we focused on thrombopoietin (TPO) and its receptor CD 110 in pancreatic cancer.
In resected specimens of pancreatic cancer, high expression of CD110 was an independent poor prognostic factor and independent predictor of liver metastasis. Inhibition of CD110 expression in pancreatic cancer cells significantly reduced migration / invasion ability of pancreatic cancer cells. In CD110-positive pancreatic cancer cells, ERK and MYC were activated by TPO administration, and cell proliferation was increased. These results suggested that TPO - CD110 - ERK - MYC signal might be involved in liver metastasis in pancreatic cancer.

Free Research Field

医歯薬学