2016 Fiscal Year Final Research Report
Basic research for elucidation and control of lymphatic metastasis for pancreatic cancer
| Project/Area Number |
26462067
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Kagoshima University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | リンパ節転移 / リンパ節微小環境 / 上皮間葉移行 / 血行性転移 / 炎症 |
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| Outline of Final Research Achievements |
1. M2-tumor associated macrophages those differentiated to immunosuppression increase lymphangiogenesis and promote lymphatic metastasis in pancreatic cancer.TAM that express folate receptor-β play important roles in invasion and metastasis via angiogenesis in pancreatic cancer.2. Pretreatment serum CA 19-9 and DUPAN-2 levels, and expression of p53 and PDGFR-β in the primary tumor are predictors of hematogenous metastasis; and important factors for determination of therapeutic strategy for pancreatic cancer.3.MicroRNA screening using a next-generation sequencer revealed that FZP36L2 which is regulated by microRNA-375 increase invasive ability of pancreatic cancer cells and promote tumor progression.4. We identify a novel metastasis suppressor gene HMP 19 by genome-wide shRNA screening using non-metastatic pancreatic cancer cell line and revealed the mechanisms of inhibition of progression and invasion.
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| Free Research Field |
消化器外科
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