Model to predict the risk of intra-abdominal abscess after pancreaticoduodenectomy by analysis of cytokine in bile

2016 Fiscal Year Final Research Report

• Project/Area Number: 26462072
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Wakayama Medical University
• Principal Investigator: Kawai Manabu 和歌山県立医科大学, 医学部, 准教授 (40398459)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 膵頭十二指腸切除術 / 術後合併症 / 胆汁 / サイトカイン / 網羅的解析

Outline of Final Research Achievements

The aim is to evaluate the impact of cytokine to predict intra-abdominal abscess after pancreaticoduodenectomy by analysis of cytokine in bile. Cytokine including IL-1α、IL-1β、IL-4、IL-6、IL-8、IL-10、IL-13、MCP-1、IFN-γ、TNF-α in bile which was collected intraoperatively were measured by global analysis. Levels of IL-1α、IL-1β、IL-4、and TNF-α in bile of patients with intra-abdominal abscess after pancreaticoduodenectomy were significantly higher than those of patients without intra-abdominal abscess. Furthermore studies should be required to detect cut-off levels of IL-1α、IL-1β、IL-4、and TNF-α in bile to predict the risk of intra-abdominal abscess after pancreaticoduodenectomy.

Free Research Field

消化器外科学