• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2017 Fiscal Year Final Research Report

Analysis of cardiac allograft protective effect by HMG-CoA reductase inhibitor and anti-BTLA monoclonal antibody

Research Project

  • PDF
Project/Area Number 26462093
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Cardiovascular surgery
Research InstitutionTeikyo University

Principal Investigator

Hara Masanori  帝京大学, 医学部, 助手 (90385849)

Co-Investigator(Kenkyū-buntansha) 内山 雅照  帝京大学, 医学部, 助手 (60713295)
Project Period (FY) 2014-04-01 – 2018-03-31
KeywordsHMG-CoA還元酵素阻害薬 / マウス / 心臓移植 / 拒絶反応 / 冠動脈 / 内膜肥厚 / 制御性T細胞
Outline of Final Research Achievements

We investigated the effects on the graft survival of HMG-CoA reductase inhibitor Pravastatin, an anti-arteriosclerosis drug, in the murine cardiac transplant model. Our models injected intraperitoneally with one dose of 10 µg/day of Pravastatin for 7 days after grafting had the significant prolongation of graft survival and the generation of regulatory T cells. Morphometric analysis showed the suppression of intimal hyperplasia in left coronary arteries of donor B6 heart from Pravastatin-exposed recipients. Moreover, the addition of Pravastatin to allogeneic mix leukocyte culture could inhibit alloproliferation in a dose-dependent manner. This study has been published in Transplantation Proceedings.

Free Research Field

心臓血管外科学

URL: 

Published: 2019-03-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi