Efficacy of treatment for periodontitis in peripheral artery disease

2016 Fiscal Year Final Research Report

• Project/Area Number: 26462102
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular surgery
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: Inoue Yoshinori 東京医科歯科大学, Tokyo, 准教授 (70280964)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 閉塞性動脈疾患 / 歯周病 / ペントラキシン3 / 反応性充血指数 / 血液誘電率 / トロンボモジュリン

Outline of Final Research Achievements

In 40 patients with peripheral arterial disease, moderate and severe periodontitis were detected in only two patients. Ischemic severity, ankle brachial pressure index (ABI), reactive hyperemia index (RHI) were evaluated, and pentraxin 3 (PTX 3), thrombomodulin, and dielectric blood coagulometry (DBCM) were measured in 90 patients with arteriosclerosis obliterans. ABI was correlated with RHI significantly by multiple regression analysis. Ischemic severity showed strong correlation with PTX3, which seemed to be useful for prediction of disease severity in PAD patients. Thrombomodulin exhibited higher value (20.3U/ml) in RHI high group being compared with RHI low group. DBCM became lower in 10 MHz 30 minutes in patients with severe periodontitis.

Free Research Field

血管外科