Involvement of B cells in development of abdominal aortic aneurysm

2017 Fiscal Year Final Research Report

• Project/Area Number: 26462104
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular surgery
• Research Institution: Hamamatsu University School of Medicine
• Principal Investigator: Sasaki Takeshi 浜松医科大学, 医学部, 技術専門員 (20397433)
• Co-Investigator(Kenkyū-buntansha): 成 憲武 名古屋大学, 未来社会創造機構(医), 特任准教授 (30378228)
• Co-Investigator(Renkei-kenkyūsha): UNNO Naoki 浜松医科大学, 医学部, 特任研究員 (20291958)
• Research Collaborator: SATO Kohji 浜松医科大学, 医学部, 教授 ; KUZUYA Masafumi 名古屋大学, 大学院・医学系研究科, 教授 ; TANAKA Hiroki 浜松医科大学, 医学部, 助教 ; SANO Masaki 浜松医科大学, 医学部, 助教 ; TAKEMURA Ayana 浜松医科大学, 医学部 ; KATO Sachiho 浜松医科大学, 医学部
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: 腹部大動脈瘤 / B細胞 / IRA-B細胞 / サイトカイン / GM-CSF / 炎症細胞

Outline of Final Research Achievements

Abdominal aortic aneurysm (AAA) is a common disease among elderly individuals. Innate response activator (IRA)-B cells synthesize granulocyte macrophage colony-stimulating factor (GM-CSF), and facilitatory and inhibitory effects of GM-CSF on atherogensis have been reported. However, the role of IRA-B cells in AAA formation is not clear. Therefore, we investigated localization of IRA-B cell like cells in AAA lesion, and the expression of GM-CSF and its receptor.
The expression of GM-CSF and some markers of IRA-B cell were observed in AAA lesion, and significantly higher expression of GM-CSF in AAA lesion was observed compared with control. In addition, GM-CSF receptors and its higher expression also were detected in AAA specimen. Furthermore, the GM-CSF receptors were identified in macrophages and neutrophils. These results suggest that IRA-B cell like cells localized in AAA lesion, and GM-CSF derived from IRA-B cell like cell and its receptor may participate in AAA formation.

Free Research Field

循環器学、解剖組織学