2016 Fiscal Year Final Research Report
Clinical study on the protective effect of ischemic preconditioning against spinal cord injury
| Project/Area Number |
26462110
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cardiovascular surgery
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| Research Institution | Yamaguchi University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 虚血プレコンディショニング / 脊髄虚血保護 |
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| Outline of Final Research Achievements |
GDF15 is known as one of ischemia-reperfusion protective factors. The GDF15 expression level in CD34-positive bone marrow cells was higher compared to CD34-negative bone marrow cells and PBMNC in C57BL/6 mice. Ischemic preconditioning was performed in abdominal aorta of mice. MicroRNAs was extracted from plasma exosomes at 24 hour after IPC. MicroRNA microarray analyses were performed using miRNA Oligo chip. IPC was performed for patients undergoing thoracic stent graft. MicroRNAs was extracted from serum exosomes before surgery and at 24 hour after IPC. MicroRNA microarray analyses were performed using miRNA Oligo chip. Expression level of one microRNA targeting ANGPT1 was downregulated in IPC treated patients undergoing thoracic stent graft.
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| Free Research Field |
心臓血管外科
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