Synergistic effects of hypoxic preconditioning with apelin administration on cell-based therapy.

2016 Fiscal Year Final Research Report

• Project/Area Number: 26462111
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular surgery
• Research Institution: Yamaguchi University
• Principal Investigator: SUEHIRO Kotaro 山口大学, 医学部附属病院, 助教 (10569312)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 細胞移植治療 / 下肢虚血 / 低酸素プレコンディショニング / アペリン

Outline of Final Research Achievements

Cell-based therapy for severe hindlimb ischemia is promising in its effectiveness and safety. However, it is necessary to be improved in effects of cell-based therapy for hindlimb ischemia because of its poor therapeutic outcomes. In this study, we investigated if hybrid strategy which is composed by transplantation of preconditioned peripheral blood mononuclear cells and co-administration of apelin was useful therapy for severe hindlimb ischemia. As a result, this hybrid therapeutic strategy resulted in effective maturation of new vessels by cell-based therapy. This strategy will be expected to become novel and low invasive therapeutic approach for severe hindlimb ischemia.

Free Research Field

血管外科