Cytokine valance in Patients with Immunoglobulin G4-Related Aortic Aneurysm

2016 Fiscal Year Final Research Report

• Project/Area Number: 26462119
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular surgery
• Research Institution: Department of Clinical Research, National Hospital Organization Kanazawa Medical Center
• Principal Investigator: Kasashima Satomi 独立行政法人国立病院機構(金沢医療センター臨床研究部), その他部局等, その他 (20444200)
• Co-Investigator(Renkei-kenkyūsha): KAWASHIMA Atsuhiro 金沢医療センター, 臨床検査科, 病理診断科, 部長 (90303304) ; KASASHIMA Fuminori 金沢医療センター, 心臓血管外科, 医長 (90303304) ; MATSUMOTO Yasushi 金沢医療センター, 心臓血管外科, 部長 (20262579)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 大動脈瘤 / IgG4関連疾患 / サイトカイン

Outline of Final Research Achievements

In this study, we identify a cytokine profile in the blood and local tissue of the patients with IgG4-AA, IgG4-AA), non-IgG4-related inflammatory abdominal aortic aneurysm, atherosclerotic AAA, almost normal aorta without dilatation were examined by (1) serum levels interleukin (IL)-4, IL-10, IL-13, and interferon (IFN)-g; (2) using resected the aortic tissues, immunohistochemical and mRNA-in situ hybrydization (ISH), local expression of the cytokines described above, CD34 , and CD163. Serum IL-10 in IgG4-AA were significantly higher than in atherosclerotic arteriopathies. IL-13 levels were elevated in 2 patients, all with IgG4-AA. Immunohistochemical analysis revealed that the number of immunopositive cells for IL-4, IL-10 and IL-13 were increased significantly in the adventitia of IgG4-AA than in aAAA and autopsy controls. ISH confirmed IL-10 and IL-13 mRNA expression in the adventitia of IgG4-AA. Co-expression of IL-13-mRNA and CD34-mRNA or CD168-mRNA was detected in IgG4-AA.

Free Research Field

組織形態学