Mechanisms of histone-induced lung reperfusion injury after lung transplantation

2016 Fiscal Year Final Research Report

• Project/Area Number: 26462123
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Respiratory surgery
• Research Institution: The University of Tokyo
• Principal Investigator: Anraku Masaki 東京大学, 医学部附属病院, 特任准教授 (70598557)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: ドナー肺障害 / ヒストン障害 / 移植 / 虚血再灌流障害

Outline of Final Research Achievements

Histone is one of intra-nucleoous proteins that could act as so-called danger signal that leads to tissue inflamation and subsequent tissue injury. Massive histone release into the blood stream can be observed when critical tissue damage(eg, brain stroke, SAH, trauma, and so on) occurs. In this project, we had investigated the histone-induced lung injury in the setting of lung transplantation. Significant lung graft damages after lung transplantation with histone-pretreated lung graft in a rat transplant model was observed. Recombinant thronbomodulin was found to have anti-hypoxic lung injury effects, but minimal effects as anti-inlammatory reagent.

Free Research Field

肺移植